07 December 2012

All Cyborgs Now: Hippocampal Pacemaker in Alzheimer's



This article is adapted from an article published on Al Fin Longevity




Johns Hopkins researchers are implanting electronic "pacemaker" devices in the brain fornix -- the nerve input to the hippocampus -- in Alzheimer's patients. This study is a follow-on to an earlier Canadian study which showed promising results for such a procedure.
The surgery involves drilling holes into the skull to implant wires into the fornix on either side of the brain. The fornix is a brain pathway instrumental in bringing information to the hippocampus, the portion of the brain where learning begins and memories are made, and where the earliest symptoms of Alzheimer’s appear to arise. The wires are attached to a pacemaker-like device, the "stimulator," which generates tiny electrical impulses into the brain 130 times a second. The patients don’t feel the current, Rosenberg says.

For the trial, all of the patients will be implanted with the devices. Half will have their stimulators turned on two weeks after surgery, while the other half will have their stimulators turned on after one year. Neither the patients nor the doctors treating them will know which group gets an early or later start.

"Deep brain stimulation might prove to be a useful mechanism for treating Alzheimer’s disease, or it might help us develop less invasive treatments based on the same mechanism," Rosenberg says.

By 2050, the number of people age 65 and older with Alzheimer’s disease may triple, experts say, from 5.2 million to a projected 11 million to 16 million, unless effective treatments are found. _Johns Hopkins _via_ ExtremeLongevity
The actual deficit in Alzheimer's involves multiple breakdowns in both neural pathways and processing centres of the brain. A "brain pacemaker" which keeps the hippocampus primed and healthy, should help tremendously in the early and middle stages of the disease. It may even prolong the early and middle stages -- postponing the final decline of mental function.

But to actually cure Alzheimer's disease, scientists will need to understand the underlying processes and predispositions much more clearly.

In the meantime, any route to improvement and mitigation is likely to be welcome, by most sufferers and their families.

Daily Mail report on this story

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14 September 2012

We Are All Cyborgs Now: Brain Implants that Think

A collaborative team of US scientists have developed a neural prosthesis which seems to exhibit the ability to restore lost cognitive functions -- and even to improve the function above the normal ability.

The study was performed in monkeys, but the findings will almost certainly apply to human brains, with the proper safeguards and modifications.

More from Technology Review:
The researchers used an array of electrodes to record the electrical activity of neurons in the prefrontal cortex of monkeys while they performed a memory task. The prefrontal cortex is involved in decision making and directs many types of cognitive responses associated with memory or other types of information processing.

The five monkeys in the study were trained to play a matching game in which they were shown an image on a screen and then had to use hand movements to steer a cursor to that same image out of two to seven others that they were shown anywhere from one to 90 seconds later.

...From their recordings in the prefrontal cortex, the research team extrapolated a mathematical model of the electrical activity of neurons involved in the movement decision. The study authors had previously shown that this kind of mathematical model, called MIMO—short for multi-input/multi-output—could interpret and replace memories in rats with the neural implant (see "A First Step Toward a Prosthesis for Memory").

In the new study, the model took multiple signals produced by the brain layer that integrates sensory information related to the task. It then extracted the relevant information to choose a particular movement. The implant can stimulate neurons in order to influence the decision to move the hand to select the correct image.

To test the implant's ability to improve or recover the decision process, the researchers gave the monkeys cocaine intravenously, since cocaine disrupts decision making. Without the activity of the implant, cocaine-affected monkeys frequently could not choose the correct image. But with the device, their decision making was on par, if not slightly better, than normal, even under the influence of cocaine. _TechnologyReview

This research represents the early stages of a neuroscientific campaign to gain the ability to replace damaged brain tissue after trauma, stroke, tumours, and abscesses -- as well as the ability to compensate for non-functioning and atrophied tissue from degenerative diseases such as Alzheimer's and Parkinson's.

It will be decades more before such prostheses are able to restore brain damaged persons to normal function -- or to convert normal brains into super-brains. But even marginal and incremental improvement can make a huge difference in the lives of those with brain impairment -- and in the lives of their families and caretakers.

Study Abstract

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27 June 2012

Human 2.0: Surviving On 1 Oz of Water a Day

This article was previously published on Al Fin Potpourri blog

How could you re-design your body so that instead of requiring over 2 litres per day of water, you suddenly need only about 30 ml to survive in good health?

Such a radical reduction in daily water requirements suddenly opens up large areas of the planet for human habitation -- from the deserts to the poles to the open ocean and more.

Reducing human water requirements also makes it easier for humans to live in outer space habitats and on long-distance spaceships. The video below describes one approach to the problem.

Video via Takram (h/t Popsci)

The video describes the Shenu Hydrolemic System, which works to limit water losses through perspiration, urination, and feces through multiple body implants and prostheses.
We were given a vision of cathartic future. A world in which humanity experiences a cataclysmic sequence of events that will bring us to the brink of annihilation. Afflicted by manmade causes, the rising sea level, radioactive emissions and release of hazardous materials into the environment, art and culture cease to exist. This provides an opportunity, not lament, to re-evaluate what constitutes art, design, culture and the quality of life itself when all prejudices and preconceptions vanish.

With this premise, takram was tasked to design a water bottle.After a period of thorough research and analysis, takram reached an uncanny solution. Our conclusion was that it would make more sense, in fact, to regulate how much water the human body can retain and recycle in this dire environment. This revelation resulted in the Hydrolemic system, a set of artificial organs. _Takram

Watch the short video, and follow the link above for more information.

The human body is in for some radical re-design, as humans attempt to expand their activities into more and more extreme environments. From the polar regions to the deep seas, to high altitude atmospheric regions, to the many environments available off-planet -- humans are looking to extend their reach and expand their practical vision.

We were not evolved for most of those environments, however. We can compensate for some of these evolutionary deficiencies by creating artificial environments around us. Submarines allow us to live and work at depth undersea. Spaceships can protect us from vacuum and temperature extremes in space, with partial protection from radiation hazard. Pressurised capsules could allow us to live at high altitudes either on mountaintops or in large high altitude lighter than air habitats.

But we are the naked ape, and we would rather be able to face these exotic environments with a minimum of artifact between us and the environment -- if we could do so safely.

That is why reducing the daily water requirement is just the beginning for the grand project of re-designing humans for the challenges ahead of us.

Much more on this topic in future postings.

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17 May 2012

The Fight to Control the Human Future: Round I

Round I: Green Global Juggernaut vs. Superhuman AI


Contender #1: The Great Green Global Juggernaut Grabs for Control
Getting Back to the Garden

Forty years ago, two ideas about humanity’s relationship with the natural world caught the imagination of the richest and most influential people. The first was that the demands of a growing population were taking more from the planet than could be replaced by natural processes. The second, related idea was that there exist natural ‘limits to growth’. These two reinventions of Malthusianism became the basis of a new form of global politics, which has sought to [control] human industrial and economic development ever since...

In 1972, the UN held its Conference on the Human Environment, and began its environment programme, UNEP. In 1983, the World Commission on Environment and Development ... was formed, leading to the publication of its findings in 1987 in Our Common Future. Also known as the Brundtland Report, it became the bible of ‘sustainable development’.

Having established sustainable development as an imperative of global politics, more organisations and programmes under the UN were formed to deliver it. In 1992, the UN Conference on Environment and Development, the first ‘Earth Summit’, was held in Rio, leading to the Agenda 21 ‘blueprint for a sustainable planet’, UN conventions on climate change and biodiversity, and the creation of the UN Commission on Sustainable Development (UNSCD). Since then, an entire ecosystem of global, national, governmental and non-governmental organisations has emerged, to advocate and implement the closer integration of human productive life with knowledge about the environment: to observe the ‘limits to growth’. The most notable of these is the UN Framework Convention on Climate Change (UNFCCC), under which a global agreement to limit greenhouse gas emissions is being sought.

...why are world leaders set to meet next month in Rio at the United Nations Conference on Sustainable Development?

The conference, known as Rio+20, aims to bring together‘world leaders, along with thousands of participants from governments, the private sector, NGOs and other groups’ to ‘shape how we can reduce poverty, advance social equity and ensure environmental protection on an ever-more crowded planet to get to the future we want’....It’s not for you or I to decide what ‘the future we want’ will look like by participating in democratic processes. Instead, ‘world leaders’ from governments, businesses and NGOs are to decide it for us. _Spiked_via_GWPF
It is worth reading the entire article, to get a better feel for how and why the extreme elitists of the global green movement aim to take control of the human future. Perhaps the key point is that a world designed by the green elite will contain far fewer human beings than the one we live in. Can you say, "Downsize?"

Contender #2: Superhuman AI Lags Behind, but Offers a Deeper Contentment


Computer Taking Control

"Any intelligence is dangerous, and any intelligence that doesn't share your goals is doubly dangerous, and any constraint we could devise for the AI merely pits human intelligence against superhuman intelligence, and we should expect the latter to prevail...."

..."AI would be able to use its superpowers to accumulate vast fortunes on the stock exchange, or even 'be Google', as AI would be cheaper and more productive than the human workers currently employed. It could even be a Super Clinton or Super Goebbels, able to take over by persuading us to let it." Or it may gain more powers that we have not even thought of, given that "the space beyond human intelligence is vast".

...any superintelligent AI "may quickly learn to tell the human testers what they want and then manipulate them", as would any AI that was isolated in some kind of "oracle". "Wouldn't you?" he adds. _Wired.co.uk

Computer Multitasking Human

Decades are likely to pass before we reach the point where superhuman AI will be able to fool us into letting it take control. In the meantime, we are already making ourselves and our societies hugely dependent upon an ever-expanding infrastructure of computing. As our lives, livelihoods, and identities come to require advanced computing more and more, we become more like powerful cyborgs, and less like native humans.
A team at the Massachusetts Institute of Technology has developed an experimental system that can detect when a human is trying to multitask, and help out.

...When Brainput detected that the driver was multitasking, it was able to detect one of the robots to use its own sensors to help navigate -- making it partially autonomous. The operator's overall performance improved, as a result, with little additional effort, and they didn't seem to notice or get frustrated by the bot's autonomous behaviour while multitasking.

..."Multitasking has become integral in many aspects of our lives, so there are opportunities to explore Brainput in other tasks and domains," said the team in a paper (.pdf) detailing the project. "In any activity involving multitasking or information overload, we could expect to see improvements in the user's performance and experience. Some examples of other domains are complex data analytics, air traffic control and management of multiple unmanned vehicles."

They added that future work could consider other cognitive states where humans could do with a helping hand from a machine. "An exploration of the system's ability to distinguish other states could lead to new enhancements at little to no cost to the operator." _Wired.co.uk
Perhaps Brainput could help us relax and enter a state of bliss whenever we are not working and performing vital tasks. Brainput might even instill in us a greater sense of purpose, of devotion to a higher goal, which would make it all worthwhile.

;-)
The global green juggernaut vs. superhuman AI. Being downsized out of existence vs. merging with the machine. These are the contenders before us today, of all of those who wish to control the human future. Something to contemplate.

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30 November 2011

The Incredible Shrinking Spy

The new generation of spies tend to be on the small side. Some of the new, advanced mobile "bugging" devices actually are bugs: insect cyborgs to be more precise.
SD

Professor Khalil Najafi, the chair of electrical and computer engineering, and doctoral student Erkan Aktakka are finding ways to harvest energy from insects, and take the utility of the miniature cyborgs to the next level.

"Through energy scavenging, we could potentially power cameras, microphones and other sensors and communications equipment that an insect could carry aboard a tiny backpack," Najafi said. "We could then send these 'bugged' bugs into dangerous or enclosed environments where we would not want humans to go." _SD
These tiny, stealthy spies can retrieve information from places you would never dream of sending one of your human agents. And the process of miniaturisation has just begun.
Image Source
Above you see a type of wasp known as the "fairy fly." It is smaller than an amoeba, and roughly the size of a paramecium. Imagine such a mini-wasp outfitted with a full kit of spy equipment. Where could such a tiny spy not go?

Well, of course your cyborg insects would be vulnerable to insecticide. Which is one reason why you would want to pursue research into non-cyborg miniature spy machines. But evolution has a long head-start on artificial nano-machine makers. There is a great deal which we must learn before we are able to mimic living miniature machines in terms of functionality.

The new generation of miniature machine makers will have to learn from nature, rather than to attempt the enterprise from scratch. Even Eric Drexler has been forced to move away from his early "diamondoid architecture" in pursuit of more proven nano-machine materials.

As for the concept of nano-spies, expect it to take off. Literally. An upcoming 2012 space mission aims to launch 4 nano-satellites. And that is only the beginning.

Expect invisible spies to surround you wherever you go -- whether at sea, on land, in space, or underground. Some living, some pure machine, some half machine and half animal. It is a new era, in which it becomes more difficult to remain invisible.

Consider your counter-measures. And consider stocking up on insecticides and advanced insect repellants. Your privacy may depend upon it.

Originally published at Al Fin, The Next Level

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21 November 2011

Brief Optogenetics Primer: All Cyborgs Now

Dr. Deisseroth shows me a video of a mouse placed in a cage with another mouse. The mouse is active and gregarious, showing interest in his new pal. A video of the same mouse, after a flash of blue light has boosted his brain's "excitation" cells (a type of overactivity found in autism), is remarkably different. After a moment's curiosity, he turns his back and shuffles into a corner. He remains remote, seemingly overwhelmed, and moves away when the other mouse gets close. For 30 minutes after that split-second burst of light, this mouse is not himself. _WSJ


Optogenetics is the combination of genetics and optics to control well-defined events within specific cells of living tissue. It includes the discovery and insertion into cells of genes that confer light responsiveness; it also includes the associated technologies for delivering light deep into organisms as complex as freely moving mammals, for targeting light-sensitivity to cells of interest, and for assessing specific readouts, or effects, of this optical control.


What excites neuroscientists about optogenetics is control over defined events within defined cell types at defined times—a level of precision that is most likely crucial to biological understanding even beyond neuroscience. The significance of any event in a cell has full meaning only in the context of the other events occurring around it in the rest of the tissue, the whole organism or even the larger environment. Even a shift of a few milliseconds in the timing of a neuron's firing, for example, can sometimes completely reverse the effect of its signal on the rest of the nervous system. And millisecond-scale timing precision within behaving mammals has been essential for key insights into both normal brain function and into clinical problems such as parkinsonism. _Karl Deisseroth _ Scientific American
Karl Deisseroth is at the forefront of the exciting science of brain control via light triggered gene expression. The video above presents a quick overview, and the Scientific American article by Deisseroth himself gives a bit more background information.

Researchers are taking this new tool and moving quickly to discover how the deep neural brain codes are transmitted and understood from one brain region to another. Here is the Nature abstract from some rather recent research from Deisseroth's lab:
Neuronal activity patterns contain information in their temporal structure, indicating that information transfer between neurons may be optimized by temporal filtering. In the zebrafish olfactory bulb, subsets of output neurons (mitral cells) engage in synchronized oscillations during odour responses, but information about odour identity is contained mostly in non-oscillatory firing rate patterns. Using optogenetic manipulations and odour stimulation, we found that firing rate responses of neurons in the posterior zone of the dorsal telencephalon (Dp), a target area homologous to olfactory cortex, were largely insensitive to oscillatory synchrony of mitral cells because passive membrane properties and synaptic currents act as low-pass filters. Nevertheless, synchrony influenced spike timing. Moreover, Dp neurons responded primarily during the decorrelated steady state of mitral cell activity patterns. Temporal filtering therefore tunes Dp neurons to components of mitral cell activity patterns that are particularly informative about precise odour identity. These results demonstrate how temporal filtering can extract specific information from multiplexed neuronal codes. _Nature
More information on this recent research from press release information

Optogenetics is a tool of discovery and a tool of control. Light can trigger changes in cells, but it can also serve to send return information about the state of cells back to the sender. Even more usefully -- for cyborg controllers -- light does not interfere with electromagnetic imaging methods such as EEG, EMG, or MRI. One can send controlling signals to the cyborg while simultaneously observing reactions to the signal, via multiple channels of observation.

Always keep in mind the "genetic" aspect of optogenetics. This type of cyborg has been "branded" with new genetic programs which will go on operating for as long as they can be triggered effectively. These new programs will eventually be able to completely override many of the innate "brain programs" of the cyborg, allowing controllers to use the entire cyborg as something of a "social probe," or a social agent.

This should demonstrate the superiority of cyborgs over zombies. Zombies operate on a limited autonomy and competence, with generally destructive effects. Cyborgs, on the other hand, can possess significant competence of a revisable nature, while sacrificing as much or as little autonomy as necessary for the task at hand.

It is the future. Why fight it? Resistance is futile. ;-)

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01 November 2011

We Are All Cyborgs Now: Getting to Genuine Convergence

Brain Riken Research

Convergent technology refers to the combination of multiple functions into a single device. Consider a computer pad which might be used for web browsing, as a video camera, as a game player, a communications device, a media player, a book reader, a data archiver, a photo album, and so on. With enough storage, a person could download much of his life onto an inexpensive handheld device, for easy reference. Useful for those with memory problems, and for everyone else as well.

But I am referring to a higher order of convergence and interactivity, which approaches the level of cyborg augmented reality. Let's use some recent research from Stanford as a springboard into the concept:
Ian Gotlib's group at Stanford University, California, studies girls aged 10 to 14 years whose mothers suffer from depression. Such girls are thought to be at higher-than-normal risk of developing the condition themselves, in part because they may inherit their mothers' tendency to "amplify" unpleasant information. Although none of the girls has yet experienced a depressive episode, Gotlib has found that their brains already overreact to negative emotional stimuli – a pattern they share with their mothers and other depressed people.


Gotlib is studying whether these young subjects can use interactive software and brain-imaging hardware to "rewire" their brains by unlearning this negative bias. In a pilot experiment, eight girls used a neural feedback display to learn how to control activity in a network of interrelated brain regions that have been linked to depression – these include the dorsal anterior cingulate cortex, anterior insula and dorsolateral prefrontal cortex.


The level of activity in this network was measured using an functional MRI scan and displayed to the girls in the form of a thermometer on a computer screen. The girls were shown sad or negative pictures that might ordinarily raise their "temperature", and tried to lower that "temperature" by adopting more sanguine mental states. They were then advised to try to recreate that mindset in their daily lives.


A control group unknowingly watched someone else's scan output instead of their own, so they didn't actually learn how to control their brain activity. _NewScientist
An interesting setup, using fMRI neurofeedback. But the researchers went further, and tested another group of girls with a much simpler setup to see how the two approaches would compare.

Another set of girls in the pilot experiment received their training through a simple computer game instead. In this game, a pair of faces appeared on a screen every few seconds: they would be either neutral and sad, or neutral and happy. Then a dot replaced one of the faces, and the "game" was to click on the dot. For the eight girls in the control group, the face replaced by the dot was selected at random, but for eight girls in the experimental group, the dot always replaced the more positive face in the pair. Over a week of playing this game daily, these girls were in effect being trained to avoid looking at the sad faces.


Gotlib himself originally found this concept, called attentional-bias training, so simplistic that he bet Colin MacLeod, a psychologist at the University of Western Australia in Perth who pioneered the technique, that it would not alter psychological symptoms. Gotlib lost his bet.


In his pilot study, both kinds of training significantly reduced stress-related responses – for example, increases in heart rate, blood pressure and cortisol levels – to negative stimuli. These stress responses are a key marker of depression, and they diminished one week after training. The girls in the experimental groups also developed fewer defensive responses to negative faces, such as startled blinking. Control groups showed no such improvement.


...Gotlib is adding more subjects to the training programme and plans to compare their long-term mental health with a parallel cohort of 200 girls, half of whom have depressed mothers, who aren't participating in the study.


He presented his results at the annual meeting of the Society for Research in Psychopathology in Boston in September. _NS
A simple computer game is much less expensive than a huge fMRI machine. And it would be easier to incorporate into one's pad computer as well. Of course, EEG neurofeedback would serve as well for this purpose as fMRI, and EEG could be incorporated into a pad computer. Can you see the convergence beginning to form?

This type of research could easily lead to much broader applications which could detect when we started to fall into a dysfunctional mental feedback loop, and provide timely stimuli which lead us back toward our predetermined goals. Why might we need such devices? Why not just use willpower and heightened consciousness instead?

The many functions where a human brain is superior to a computer depend upon the way that the brain is wired, and how the different parts of the brain communicate. This is virtually all below the level of consciousness, making us largely subconscious machines -- or zombies -- in many of our most important aspects. But ironically enough, by becoming more cyborg-like, we may be able to become less zombie-like.

Brain-computer interfaces (BCI) are typically thought of in terms of helping persons to either compensate for neurological deficits such as stroke or paraplegia, or to rehabilitate from neurological damage. BCIs are also beginning to be utilised in the gaming world, to provide more intuitive game playing. We can also expect much more use of BCIs in the educational environment, for enhanced learning.

It is difficult to explain the explosively revolutionary impact of this type of technology, when used as neurofeedback for learning, mood enhancement, creative invention, mental focus, relaxation, and social interaction. You may think that intervention with such hyper-convergent technology would begin sometime after the birth of a child, but you would probably be wrong.

Once humans discover the revolutionary impact of hyper-convergent computing and BCIs on child raising outcomes, for large segments of the population there will be no going back. Why? Because it is almost inevitable that new, previously unknown critical developmental windows will be discovered, for high level skills that are currently developed only by accident. These windows will be discovered because the new BCIs will not simply be passive monitoring and feedback devices, but will also be "mental probes" using various modalities. You never know what is there until you go in and look.

This is very dangerous territory, where angels fear to tread. But then, as we approach cyborg-hood, we may find ourselves further away from angelhood. Heightened awareness, knowledge, and competence tend to lead us to test ourselves to greater extremes. Some of the things we try may go catastrophically wrong. We have to accept that in advance and take appropriate precautions as we proceed.

One of the greatest dangers is the danger of losing something essential, something perceptive and wise which keeps us from making fatal mistakes, and from falling into traps and wasting time on dead end enterprises. We could easily grow so dependent upon our machine alter egos that we lose much of our natural strength and competence.

That is why the great majority of humans will remain as a control group. At least at first. It will be difficult to keep persons from adopting a technology which may give them an advantage in life outcome, and which is likely to become both widely available and inexpensive, over time.

In addition, periodic mandatory periods of going "offline" would force us to reclaim our "naked human abilities." Failing to take such precautions could leave us extremely vulnerable to an unexpected failure of our technology.

A recent posting here looked at a program for developing a platform for "rebooting civilisation" in case of catastrophic failure. A simple BCI system would make it much easier to build and maintain these essential machines of basic civilisation. BCIs and wearable computers / data archives, could be stored in secure caches, safe from natural and man-made disaster. A primitive version of that idea was presented in the Niven - Pournelle SF novel, "Lucifer's Hammer," where the astrophysicist character stored a precious collection of reference books in a safe and secure cache -- the books were later used to help reboot civilisation. You can imagine how much more effective full sensory neurofeedback BCI archiving would be.

It may seem a long distance from the Stanford research above to the lifelong cyborg existence described. But it is mostly a matter of engineering and experimentation. When Steve Jobs, Steve Wozniak, Bill Gates, Ted Hoff, Robert Noyce, and so many others laid the foundation for cheap, ubiquitous computing, the djinn was already out of the bottle.



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28 July 2011

We Are All Cyborgs Now: Soft-Material Memristor Brain Augmentation

One of the most-discussed memristor characteristic is its synaptic biomimesis. “State-of-the-art computers have difficulty mimicking the operation of the brain,” [NCSU Professor] Dickey notes. “Memristors, on the other hand, are effective at mimicking synapses. If you were interested in only mimicking brain function, then solid-state memristors would be more practical because they contain many more memory elements and are much more optimized at this point. One of the things distinguishing our work is that the device behaves like a memristor and has other properties similar to the brain. Conventional electronics tend to be rigid, 2-D, moisture-intolerant, and operate using electrons; the brain, in contrast, is soft, 3-D, wet, and operates using ions and in addition to adopting many of these properties, our device is composed of biocompatible hydrogels.” _Physorg
Human brains are marvelous biological machines, but they could be a lot better. It will prove easier to augment the human brain technologically than to replace it altogether with a cognitive machine. The invention of a soft-material, biocompatible computing architecture would allow the implantation of computing devices into the human body. North Carolina State University scientists and engineers have begun to invent what they hope can be such a material -- the soft-material memristor.
Prof. Orin Velev, Prof. Michael Dickey, and graduate students Hyung-Jun Koo and Ju-Hee So, have devised a new class of easily fabricated memristors based entirely on so-called soft matter – hydrogels doped with polyelectrolytes sandwiched with liquid metal electrodes – that operate using ionic conductance in aqueous systems rather than conventional electron transport.

...In essence, this suggests that in addition to having the potential to realize memristor-based neuromorphic structures, the polysaccharide hydrogel core of these devices is biocompatible, could possibly be interfaced with live neural and other tissue, and could lead to three-dimensional soft circuits and their in vivo operations.

...Going forward, Dickey continues, “We hope to take advantage of the fact the water-based gels in the device are biocompatible, and could in principle be integrated with biological species, such as cells, enzymes, proteins, and tissues. We also made no attempt to optimize the memory capacity in our prototypes, which is an area for improvement. Finally, we’re working to understand the subtle aspects of the operating mechanism.” _PO
They are still in the very early stages, but the possibility of an implantable soft, biocompatible brain augment is too important to overlook.

Quite a few different interfacing techniques could be used, but the optical approach would seem to be the least intrusive for tissues such as the brain, which are sensitive to electromaqnetic forces. Optical materials have high bandwidth and may be less likely to be bio-rejected than electrically conductive materials. Some people have discussed optical brain control in the context of optogenetics.

Another fascinating type of bio-to-machine interface is the piezoelectric interface being developed at Georgia Tech. The piezoelectric interface can be operated by exquisitely subtle mechanical movements, such as a muscle fibre twitch. In other words, a thought -- even a subconscious though -- could cause a pattern of muscle twitches which would activate a particular machine command or subroutine via the piezoelectric interface.

The human brain was not evolved for the ultra-long lifetime of a next level human. Cell debris accumulates, DNA repair mechanisms begin to fail, immune systems weaken, hormonal support falls off, etc. Scientists are learning a lot about how normal aging leads to memory loss in even the sharpest minded senior citizens. The intricate network of cellular connections in the brain slowly loses definition and resolving power.

Well-designed brain implants could sense this process occurring and engineer work-arounds to compensate for the changes. Long term solutions would require a rejuvenation treatment to restore -- or improve -- the resolving power of brain networks, but sometimes work-arounds are the best one can do at the time.

Where would you place your soft bio-compatible brain implant? There isn't a lot of room inside the skull itself, but implants could be placed under the scalp in a relatively unobtrusive manner as long as they were not too large. Alternatively, some women might choose to place their augments in the breast area, and some men might choose augments shaped to serve as muscle implants. If the connections to the interface are via optical fibre, the distance from anywhere on the human body to the brain is negligible, in terms of the speed of light. The interface itself would need to be placed close to the brain.

Depending upon its sophistication, an implanted brain augment could come to know how an individual's brain works quite well, over a period of time. Such augments could even learn how to simulate their hosts in a rudimentary way. The possibilities arising from such pseudo-emulation are worth considering, but perhaps not here and now. (See Old Man's War by John Scalzi)

It is important to stress that these NCSU memristors are not at all close to anything that could be used as a brain augment. But it seems to be the goal of the researchers there to develop biocompatible sensors and intelligent interfaces using these materials. It is not a long stretch from there to an implantable computer augmentation for the brain.

Although memristors are often referred to as neuromimetic or synaptomimetic, in the aggregate, memristor computing devices will function nothing like the brain. But they will not need to. They will only need to function like competent and clever computers that provide reliable memory and I/O capability for mental computations, speculations, and interfacing with the outside world -- including the ability to control machines mentally and to communicate remotely with machines and other individuals who have similar augments.

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01 July 2011

Neuro-Opto-Genetics and the New Cyborg Future

Using a combination of genetic engineering and laser technology, researchers at the University of North Carolina at Chapel Hill have manipulated brain wiring responsible for reward-seeking behaviors, such as drug addiction. The work, conducted in rodent models, is the first to directly demonstrate the role of these specific connections in controlling behavior.

The UNC study, published online on June 29, 2011, by the journal Nature, uses a cutting-edge technique called "optogenetics" to tweak the microcircuitry of the brain and then assess how those changes impact behavior. The findings suggest that therapeutics targeting the path between two critical brain regions, namely the amygdala and the nucleus accumbens, represent potential treatments for addiction and other neuropsychiatric diseases. _SD
It is necessary to read between the lines to understand what is being described. The scientists introduced foreign genes into selected pathways deep inside a rat's brain, then sent light via fiber-optics to trigger activity in the genetically modified pathways. The behaviour of the rats could then be controlled, using external light pulses.

By tapping into a wide variety of neural pathways -- to trigger different brain networks -- entirely different modes of behaviour could be influenced. But that is just the beginning.

The brain can be literally "played like a keyboard," with selective targeting of pathways and stimuli. Different genetic strains of opsins which respond to different wavelengths or pulse patterns of light could be implanted in brain nuclei or pathways quite close to each other, to prevent interference by neighboring brain networks. This level of fine control over the broad range of brain networks would allow the "programming" of a wide range of behaviours -- both skilled and unskilled -- over a period of time.

Utilising the brain's reward centers and pleasure centers -- but on a significantly more nuanced level than previously possible -- scientists and neuro-engineers could instill quite sophisticated behavioural repertoires in the unsuspecting cyborg's brain.

Humans are relatively unsuspecting as to the degree to which their important behaviours are influenced by miniscule quantities of natural chemicals, errant electrical stimuli, or ephemeral environmental phenomena. A sufficiently sophisticated and broad-spectrum approach to behavioural modification and programming could make even the most intelligent animal susceptible to simple light pulses. A short set of pulses might well set into motion behavioural programs which might go on for hours or longer, once the training is complete.

Just a short time spent contemplating the reinforcement pathways involved in maintaining drug addiction, or video game use, tells us that if a program of behavioural modification enlists the reward system of the brain sufficiently, it will become quasi-permanent and difficult to dis-engage, once mature.

These ideas have important implications for normal day to day human activity, at all developmental levels. Most of us will not sit still for genetic modification and implantation of optical or electrical probes. But we are being continuously programmed just the same, and our reward systems are helping to solidify this programming. It is not quite as far as some may imagine, from where we are to what is described above.

Along with the coming age of wonderful medical and psychological cures, will come free-riders of mind modification. We can either learn to tweak ourselves in ways that make us more alert, awake, and alive -- or we can join everyone else as they shuffle down the Idiocracy road.

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10 June 2011

This Is Your Life

...almost imperceptibly, numbers are infiltrating the last redoubts of the personal. Sleep, exercise, sex, food, mood, location, alertness, productivity, even spiritual well-being are being tracked and measured, shared and displayed _NYT
Secret hopes, secret fears, secret compartments stowed securely around the nooks and crannies of our minds...plus the many details of our lives that we refuse to share, and push beneath the level of consciousness. Perhaps there is no one to be trusted with secrets so deep (or so shallow). Some of these secret rooms serve a useful purpose -- even if only from time to time:
"In every heart there is a room,
A sanctuary safe and strong,
To heal the wounds from lovers past,
Until a new one comes along"
— Billy Joel _Goodreads
But we can create so many secret stashes of thoughts, whims, moods, ideas, emotions, locked and stowed away, so that even we ourselves lose track of who we are and what we want to become. But wouldn't it be better -- wouldn't WE be better -- if we were able to integrate the potential energies of these hidden stashes of personal feelings and information, and free ourselves up?

Meditation, relaxation training, creative visualisation, introspection, and positive affirmations can only take us so far. We need to actually look deeply and objectively at what we are doing and how we are progressing. And that is where the new technological tools of personal and mobile telecomputing can shine.

Decades ago, it was learned that people will reveal things to a computer which they would never confide to another person. So over the years, a computer and internet industry called "self-tracking" has grown up to provide personal tools of self-knowledge and self integration, along with a number of social tools allowing people to share what they know and are learning.
The self-tracking movement, which has sprung to life over just the last couple of years, is enabled in large part by both wireless sensing devices and smart phones. Many people already employ smart phone apps to track food intake and fitness, but a new generation of apps also tracks mood, meditation, migraines and other factors. _TechnologyReview
Self tracking is not a new phenomenon -- it is as old as the maxim "the unexamined life is not worth living." But in the new world of mobile computing and advanced wireless interfacing, self tracking is quickly expanding into new territories.
* There is no end to what can be, and will be, tracked. At each QS meeting I am surprised and amazed at the unpredictable qualities that people will monitor and the clever ways in which they will attempt to quantify them. We've seen one person (or more) track one (or more) of these: sex, dates, attention span, REM sleep, car routes, daydreams, caffeine intake, people they meet, every keystroke, arithmetic speed, allergic reactions, mood, happiness, footsteps, memory recall, body motion, and every medical and health related factor one can quantify. Also check out the lifeloggers.

* There is no end to folks hoping to make a better tool to sell to self-trackers. Like the early days of personal computers, most of the tools available now are primitive and often first cobbled together by someone for their own use. That's what makes the groups so interesting. But as what works and what is desirable settles out, slickness will move in. There's lots of money watching. _Technium

We do not need to know or reveal everything about ourselves. That would be not only impossible but imprudent. What we are looking for is ways to free and direct our flows of energy to build more satisfying lives.
Jon Cousins, an Englishman who had "bouts of dreadful depression" since his 20s but managed to hide it and be reasonably functioning in the world. In his mid-50s, he finally went to see a psychiatrist, and she told him that it seemed likely that he was bipolar: Would he mind tracking his mood for three months so that the condition could be verified? Cousins couldn't find a ready way to do this, so he started using a psychological test that was a set of 20 cards with adjectives. He also tracked his scores on a graph, noting the ups and downs in his mood.

It's when Cousins is unspooling his mood graph that he reveals that he's got a touch of the magician about him (skip to 7:25 in the video). At the end of one summer, some of his friends ask to be kept informed of his mood scores, and all of a sudden his scores rise to a high plateau and stay there. As Cousins relates, the "sheer act" of knowing that other people cared about his mood had the effect of lifting his mood. He's not cured, he still has his down days and weeks, but measuring and sharing has helped, sometimes remarkably. He's moved the whole system online to a site called Moodscope. _Slate

Quantified Self is one website which is trying to monitor the many different apps for self-tracking. Here are 154 videos providing more information on some of these apps. Here is the YouTube channel for Morning Coach, one of the most popular apps.

The idea of examining one's life under a microscope is not appealing to many people. And yet the potential power of such an examination to unleash hidden strengths and talents and to increase our personal satisfaction, makes a very compelling case in favour of self-examination and quantification.
We tolerate the pathologies of quantification — a dry, abstract, mechanical type of knowledge — because the results are so powerful. Numbering things allows tests, comparisons, experiments. Numbers make problems less resonant emotionally but more tractable intellectually. In science, in business and in the more reasonable sectors of government, numbers have won fair and square.

For a long time, only one area of human activity appeared to be immune. In the cozy confines of personal life, we rarely used the power of numbers. The techniques of analysis that had proved so effective were left behind at the office at the end of the day and picked up again the next morning. The imposition, on oneself or one’s family, of a regime of objective record keeping seemed ridiculous. A journal was respectable. A spreadsheet was creepy.

And yet, almost imperceptibly, numbers are infiltrating the last redoubts of the personal. Sleep, exercise, sex, food, mood, location, alertness, productivity, even spiritual well-being are being tracked and measured, shared and displayed. _NYT

Numbers can show us more aspects of the truth about ourselves and our worlds, allowing us to make necessary changes or to do more of what works. We still need to use the forms of meditation, introspection, affirmation etc that work for us.

And we may as well admit it now: Resistance is futile. In many ways, we are all cyborgs now. Even if we do not have machine implants and replacements, almost everyone reading this relies upon information and feedback from complex machines. The best forms of this reliance enable synergism at high levels. This is your life, your cyborg life.

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29 March 2011

Cyborg or Grobyc? You Be the Judge

Nanonerves

Human brains are amazing mental machines. As far as we know, there is nothing else quite like it in the universe. But we always wonder whether perhaps, we could build something just a bit better? Observe all the excitement and expenditure, over the past 60+ years, directed toward "artificial intelligence." What a disappointment that has been so far.

For all the different approaches that have been taken to achieve machine intelligence, most of the failures share the same feature: they rely on algorithmic digital silicon logic. This seems a bit odd, when the only proof of concept of conscious intelligence we know of -- the human brain -- utilises a distinctly and entirely different type of logic.

Here is an interesting twist on the conundrum: Why not design a neuronal scaffolding out of nanotubes made of germanium and silicon, then allow neurons to grow within the scaffolding? The neurons will naturally make networked connections with each other along the scaffold, but an added bonus may be the ability to interface the neurons with the silicon-germanium substrate of the scaffold itself.
Graduate students at the University of Wisconsin, Madison, led by Minrui Yu, have published an ACS Nano paper, "Semiconductor Nanomembrane Tubes: Three-Dimensional Confinement for Controlled Neurite Outgrowth," in which they show that they have been able to successfully coax nerve cell tendrils to grow through tiny tubes made of the semi-conductor materials silicon and germanium. While this ground-breaking research may not portend cyborgs or even human brains enmeshed with computer parts, it does open the door to the possibility of regenerating nerve cells damaged due to disease or injury.

Yu and his team, led by Justin Williams, a biomedical engineer, created tubes of varying sizes and shapes, small enough for a nerve cell to glam on to, but not so big that it could fit all the way inside. The tubes were then coated with nerve cells from mice and then watched to see how they would react. Instead of sitting idly, the nerve cells began to send tendrils through the tunnels, as if searching for a path to something or somewhere else. In some instances they actually followed the contours of the tubes, which means, in theory, that the nerves could be grown into structures. _PO
Indeed. The nerves could be grown into structures along prescribed pathways. But the possibility of a functional and powerful brain-machine interface is also being considered.
The hope of course, in this type of research, is that a way can be found to connect a computer of some sort to a group of nerve cells to reestablish communication that has been disrupted. The computer in this case could serve as a relay of sorts, allowing those who can no longer walk, for example, due to spinal injury or disease, regain their former abilities. In that regard, this particular research is even more revealing than it might at first seem, due to the fact that the tiny tubes that have been created, very closely resemble myelin, the outer insulating sheath that covers parts of normal nerve cells. _PO
This is the actual goal of the researchers in Wisconsin: to grow a nerve:computer interface. This is one approach to the brain:machine, or cyborg approach to extreme rehabilitation, or even augmentation for emergency workers or military personnel.

Another approach which is even more exotic than described above, would be to grow an intricate "nano-neural web" into the intact brain structure, to create millions of interfaces to all of the important centers of the brain. The idea behind such a grown nano-structure, besides providing an external brain:machine interface, would be to allow the conscious mind access to unconscious brain functions.

Emergent phenomena are likely to grow from the humble beginnings of such an approach. Growing a nano-neuro web interface inside an intact brain might be easier than growing one outside the brain, in some ways. The "growth front" of the web would merely need to follow pre-existing pathways, and could be assisted by internal and external feedbacks.

Alternatively, one could grow a scaffolding in vitro, according to the most advanced brain imaging, seed it with the appropriate proto-cells, and nourish it into an intricate, functioning, autopoietic neural:nano hybrid network. Any conceivable shape and combination of connections between artificially grown brain centers would be possible -- at any arbitrary and chosen level of complexity. Such an artificial -- but living -- brain could be provided with a rudimentary circulatory system, and implanted into the control structure of very sophisticated and highly connected machines and structures.

Cyborg or Grobyc? You be the judge.

Adapted from an article at Al Fin, the Next Level

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01 December 2010

Brain as Co-Processor: Grobyc Super-Computers?

Image Source

Computers lack a certain je ne sais quoi, which has prevented them from achieving the next level of quasi-intelligence. Humans, on the other hand, possess that ineffable quality in abundance, and some may be willing to share with computers -- to lift them up, closer to our level. Columbia University researchers are looking into the techniques of mind-sharing, with some interesting findings:
Most brain-computer interfaces are designed to help disabled people communicate or move around. A new project is using this type of interface to help computers perform tasks they can't manage on their own...[The] device, called C3Vision (cortically coupled computer vision), uses an electroencephalogram (EEG) cap to monitor brain activity as the person wearing it is shown about 10 images per second. Machine-learning algorithms trained to detect the neurological signals that signify interest in an image are used to analyze this brain activity. By monitoring these signals, the system rapidly ranks the images in terms of how interesting they appear to the viewer.

...At the speed at which it works, the conscious brain is unable to register a "hit." But the neurological visual pathways work much faster, says Sajda. The brain produces distinct electrical signals that can be detected and decoded by the 64 EEG electrodes within the cap. "It's on the edge of the subconscious," he says. _TechnologyReview
That is the key point, of course. By using the brain below the level of consciousness, the brain-computer hybrid -- or grobyc -- is able to function more quickly than the conscious mind, and on a higher level than a mere computer.
PDF Image Source PDF

Researchers have worked with grobycs using insect brains as controllers for several years. But it is only recently that the "mind-reading" technology has become available which allows the human subconscious -- much faster than the conscious -- to function as a computer controller.

This is the key difference between a human cyborg and a human grobyc. In the human cyborg, the human uses machine augmentation to perform tasks it could not otherwise perform. In the human grobyc, the machine uses the human brain as an adjunct to machine operation. The person's conscious mind (if any) need not be aware of the low level activity at all.

Doug Hofstadter has been writing about this slippery component of the human mind for over 30 years. It is central to the human mind's ability to think generatively and autonomously -- although outside input is crucial. It is the phenomenon of metaphorical stacking down to the embodied, non-verbal levels. It one of many critical features of mammalian general intelligence that AI researchers have ignored for over 60 years to their detriment.

Because the field of AI has neglected something so central to intelligence for so long, scientists are forced to use human brains as co-processors, and reduce human minds to grobyc status. Imagine: "My life as grobyc."

It certainly opens up entire new avenues for commerce and enterprise, to those forward thinkers looking to seize an under valued and under utilised resource to turn a profit. In the future, humans may sell the use of their subconscious minds to Google while they are sleeping, providing the mega-corporation with computational powers of search and subtle "slippery discrimination" its competition could only dream of.

More ominously, governments may use the subconscious minds of the masses to find better ways to control them en masse. This is an application to which an Idiocracy is ideally suited, unfortunately. Think of it as "following the ratings" or "following the polls", but on rocket fuel, and taken to the lowest common denominator.

Bonus: NYT article profiling "Portraits of the Mind", beautiful images of the brain
In the game of intelligence, the score is: Natural Evolution 1 AI Design 0

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29 June 2010

We Are All Cyborgs Now:

The idea that a chip can interface between inputs and outputs of certain brain area is a very new concept in scientific circles, Prof. Mintz notes, although movies and TV shows about bionic humans have been part of the popular culture for decades. _ReNaChip
The chip sits just below the skin, on top of the skull. It senses brain activity via implanted electrodes, and it knows when to fire stimulatory pulses to the precise parts of the brain where they are needed -- to restore the desired brain function.
For now, the chip, called the Rehabilitation Nano Chip (or ReNaChip), is hooked up to tiny electrodes which are implanted in the brain. But as chips become smaller, the ReNaChip could be made small enough to be "etched" right onto the electrodes themselves.

For therapeutic purposes, though, only the electrodes will be inserted into the brain. "The chip itself can be implanted just under the skin, like pacemakers for the heart," says Prof. Mintz, who is currently conducting experiments on animal models, "ensuring that the brain is stimulated only when it needs to be."

One of the challenges of the proposed technology is the size of the electrodes. The researchers hope to further miniaturize deep brain electrodes while adding more sensors at the same time says Prof. Mintz. His Tel Aviv University colleague and partner Prof. Yossi Shaham-Diamond is working on this problem.

The international multidisciplinary team, includes other researchers from TAU — Prof. Hagit Messer-Yaron and Dr. Mira Kalish — and partners from Austria, England and Spain, regularly converge on the TAU campus to update and integrate new components of the set-up and monitor the progress of the chip in live animals in Prof. Mintz's lab. _Source


More here, here, here, and here.

The ReNa chip would function as a type of "nano-controller", riding herd over specific brain centers -- depending upon the person's needs. Initially, the chips will be used for brain rehabilitation and to modulate the effects of various neuropathologies. Eventually, the chips will be used to treat behavioural problems. Climate change deniers and the like. You will be assimilated. Resistance is futile.

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29 April 2010

Cyborg Geniuses Behind Machines of War

Wired

The US military wants to boost the brainpower of soldiers as much as their physical strength, speed, and destructive power. At the same time, the DOD wants to develop better brain-machine interfaces for their super-bright soldiers.
Neuroscience is at the locus of the program, because before they can super-charge cognition, Pentagon scientists need to understand exactly how it works. So they’re launching “Neuromorphic Models of Human Social Cultural Behavior (HSCB),” in an effort to accurately model human cognition, including how we perceive, learn and retain information. HSCB models already exist, and are used by troops and decision-makers to predict the outcome of a choices during a mission. But the models “are only as good as the fidelity of the human behavior representations (HBR) that form them.” Right now, those representations are based entirely on empirical observation, which the military wants to swap out for a model that can tap into “the functions of the brain that give rise to actual human cognition.”

It’s not the first time the Pentagon’s tried to map the human mind. Last year, far-out research agency Darpa requested proposals for systems that would synchronize neural brain waves to optimize the mind’s storage capacity and memory recall. The agency’s also tried to create synthetic versions of living brains, complete with “neuroscience-inspired architecture.”

But no matter how cognitively capable troops become, they’ll still rely on computers to handle much of their workload. Humans, the solicitation notes, “are quick to arrive at initial decisions,” but computers can more quickly calculate pros and cons of different tactics. That’s why the military also wants neuroscience to “bridge the human-machine systems gap” and turn troops and computers into collaborative units. Their “Neuro-Cognitive Control of Human Machine Systems,” would tap into the neural signals that indicate desired actions, then transmit them to a computer to determine the optimal approach and carry it out.

And a training program that emphasizes brawny brains over bodies reflects a trend across Pentagon departments: Just last month, the Army announced a redesign of their physical fitness program, to accommodate troops spending more time behind computer screens than they do on their feet.
_Wired
It rather sounds as if the US military wants to develop into a back office full of nerds controlling front line armies, navies, and air forces made up of semi-autonomous machines fully brain-linked to the back office nerds. All branches of the military currently control unmanned semi-autonomous vehicles -- on air, land, sea, and undersea.

This emphasis on putting only machines in harm's way is a tacit acknowledgement of the huge expense of training the modern soldier. It also points to an army of the future that no longer distinguishes between male and female in combat roles.

If such a US military does come about, it will mean a radical change from the modern day missions of peace-keeping and "winning hearts and minds", as has been attempted in Iraq and Afghanistan. Tribal peoples will not likely give their hearts and minds to strange machines. Not even a little.

No, these cyborg armies, navies, and air forces are meant for rapid destruction of enemy forces, wherever they may be -- no doubt extending into near-Earth space. It is a logical extension of warfare, where the value of human life is considered most important. But the modern US military consists mainly of non-combat forces and non-combat roles. It remains to be seen whether the new psychology of warfare will extend into the Pentagon mentality as a whole.

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27 November 2009

Micro-Nubbin Neuron-Chip Interface


This "micro-nubbin" nerve interface-chip from IMEC provides convenient "docking stations" for nerve processes to interface. The chip is meant to serve as an experimental "eavesdropper" -- to listen in on communication between neurons. Initially, it will provide a surface for nerves to grow and interface. Scientists hope to learn something from recording how networks of neurons communicate among themselves.
IMEC presents a unique microchip with microscopic nail structures that enable close communication between the electronics and biological cells. The new chip is a mass-producible, easy-to-use tool in electrophysiology research, for example for fundamental research on the functioning and dysfunctioning of the brain. Each micronail structure serves as a close contact-point for one cell, and contains an electrode that can very accurately record and trigger in real-time the electrical activity of an individual electrogenic cell in a network.


...IMEC's new micronail chip is the ideal instrument to study the communication mechanisms between cells. The electrodes in IMEC's micronail chip are downsized to the size of cells and even smaller. They consist of tiny nail structures made of a metal stem covered with an oxide layer, and a conductive (e.g. gold or titaniumnitride) tip. When cells are applied on the chip surface, their cell membrane strongly engulfs the nail structures, thereby realizing an intimate contact with the electrode. This very close contact improves the signal-to-interference ratio enabling precise recording of electrical signals and electrical stimulation of single cells. _SD
This research is fairly mundane, as described. But Al Fin neuroscientists understand where the science is heading, and are quite excited.

The micro-nubbin chips will need further miniaturisation, and will have to be made biocompatible. In the lab, neuronal and glial proto-cells will be cultured, in contact with the micro-nubbins. The chip + precursor cells + selected growth factors will be implanted intra-cranially, and anchored to the underside of the skull. The cultured and anchored cells will send processes into the white matter of the brain via an intricate system of artificial portals -- in essence engineered artificial white matter paths from the interface to merge with established white matter pathways.   These soft tissue penetrations of the cortex would be composed of the individual's own cells, and firmly immersed within soft tissue so as not to cause damage to other structures.

Al Fin neuroscientists envision roughly a dozen of these micro-nubbin brain/machine interfaces at specific areas of the skull -- depending upon the brain systems to be interfaced. Each nubbin-hub interface will allow for roughly a thousand or more neuron-chip interface points. Visual, auditory, olfactory, motor, and memory systems will be targeted -- among others.

Clearly the initial applications will be military. First, to provide prosthetic control of artificial limbs, and to provide optic and auditory input to soldiers, sailors, airmen, and marines who have suffered brain damage. As the operational ability of the chips improves, they will be used to compensate for subtler forms of brain damage and functional impairment in military injuries.

As the chips are perfected they will be used to create nerve-machine interfacing with advanced weapons systems and remote reconnaissance systems. Then the chips will be implanted into elite combat infantry operatives.

Imagine being able to see well beyond the electromagnetic spectrum of visible light. Or to be able to hear well beyond the auditory spectrum of 20 Hz to 20 KHz. Having the ability to distinguish subtle smells better than a bloodhound. Those would be simple beginnings with much more complex capabilities downloaded later -- as improved versions are developed.

Brain-machine interfacing will allow for a wide variety of expanded human senses and function, as well as rich virtual reality and augmented reality settings. Auxiliary memory and calculation systems as well as other advantages of complex interfacing with highly advanced information systems, would also be available.

Before all these things can be done, such micro-nubbin chips will have to become "smart enough" to understand neuronal code.  That is the purpose of the initial lab studies with cultured neuronal nets.

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05 November 2009

All Cyborgs Now: SmartHand Wired to Nerve Ends

Prof. Yosi Shacham-Diamand of TAU's Department of Engineering, working with a team of European Union scientists, has successfully wired a state-of-the-art artificial hand to existing nerve endings in the stump of a severed arm. The device, called "SmartHand," resembles -- in function, sensitivity and appearance -- a real hand.

Robin af Ekenstam of Sweden, the project's first human subject, has not only been able to complete extremely complicated tasks like eating and writing, he reports he is also able to "feel" his fingers once again.

The state of the art for advanced prosthetic hands has just jumped a level -- thanks to the EU built SmartHand, and its neurally wired interface developed at Tel Aviv University.
[Hand recipient] Ekenstam told a television interviewer, "I am using muscles which I haven't used for years. I grab something hard, and then I can feel it in the fingertips, which is strange, as I don't have them anymore. It's amazing."

This particular multi-million dollar project focused on hands, but the TAU/EU team could also have built bionic legs to be wired to the brain. The team first chose to build a hand, however, because of its unique challenges. "The fingers in the hand are the most complex appendages we have," Prof. Shacham-Diamand observes. "The brain needs to synchronise the movement of each digit in a very complicated way."

With the help of the TAU team, the SmartHand project was able to integrate recent advances in today's "intelligent" prosthetic hands with all the basic features of a flesh-and-blood hand. Four electric motors and 40 sensors are activated when the SmartHand touches an object, not only replicating the movement of a human hand, but also providing the wearer with a sensation of feeling and touch. _SD

The researchers eventually intend to cover the machine SmartHand with a "skin" covering, to match the recipient's own skin tone, to create a more natural appearance. There will always be those who would rather maintain the artificial, robotic appearance for various reasons of their own, of course.

The SmartHand interface apparently utilises flexible implanted electrodes for transferring information to and from nerve endings remaining in the distal stump.  It appears to provide distinctly improved motion control and sensation both.

It should be obvious that the same technology could be used to provide non-amputees with the ability to operate and feel distant avatars and all types of remote prostheses.   If you do not mind a number of implanted electrodes in rather sensitive parts of your body, you may even pioneer the new science of "teledildonics", or sex at a distance. 

Or you may want to wait until transcranial brain implants are perfected, which can bypass lower body-interfaces altogether.

Today, you do not have that choice.  Soon, you may.

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We Are All Cyborgs Now: NeuralWisp Chip w/ remote RF Power


University of Washington researchers have developed a neural sensing chip that is powered by a remote radio frequency source up to 1 meter away. The NeuralWisp chip is currently being used to "tap into" the neural activity of moths, in order to understand the insect's locomotion. UW researchers are gradually incorporating a number of innovative size-reducing and energy-saving modifications into the NeuralWisp.
The device contains a microprocessor powered by a commercial radio-frequency reader that doubles as a data-collection device. The same equipment is used to power and read information from radio-frequency identification (RFID) tags. In experiments, the researchers used the new device to sense central nervous system activity in a moth in order to study its locomotion.


There have been some advances in reducing the size of neural implants recently, but the majority of implantable devices are still relatively cumbersome. These devices typically require multiple components--such as a clock for timing operations and an antenna for communication and power-harvesting--that are quite large compared to the transistors on the microcontroller, says Brian Otis, professor of electrical engineering at the University of Washington and lead researcher on NeuralWISP.


"You can have millions of transistors on a chip less that's less than a cubic millimeter in volume, but the problem is with the extra parts," says Otis. "Our goal is to shrink everything onto a single chip and reduce the power consumption of these components so that the chip can be wirelessly powered."


The NeuralWISP is a collection of smaller, more low-power components, such as a specialized signal amplifier, on a circuit board just over two centimeters long. A future version will integrate all components onto a single chip that's one millimeter by two millimeters in size. The circuitry converts usable power from the reader--roughly 430 microwatts--to a voltage that can turn on the microcontroller. This microcontroller, in turn, controls the sensor and its timer, and runs instructions that allow data to be sent back to the reader. _TechnologyReview
Anyone who has read John Scalzi's SF novel Old Man's War, may be reminded of the powerful brain reading devices that permitted the transplantation of 75 year old minds into the freshly grown super-bodies in which they would go to war. The old 75 year old bodies were discarded, but the memories, experiences, personalities, and seasoned characters lived on.

Clearly the technology requires a lot of development before it will be able to monitor and record the activity of human minds at that level of dynamic precision.

Long before this brain reading technology allows for transplanting minds to new bodies, it will be used to provide seamless functioning of advanced prosthetic devices and remote operation of proxy devices and avatars. They may also provide baseline healthy readings in case of later brain damage from stroke, trauma, toxicity, infection, malignancy, or gradual neurodegeneration.

Information gained from future generations of such devices on the nano-scale, may even pave the way for human level machine intelligences.

More: This approach to biodegradable implantable neurocircuits should soon allow for some very clever experiments in the art of the cyborg.

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21 February 2009

We Are All Cyborgs Now: Photoelectrode Control

A fascinating new type of brain stimulating electrode is being developed at Case Western Reserve University. This new electrode can be triggered by light, yet it triggers a nerve action potential at the brain implantation site.
The team led by Ben W. Strowbridge and Clemens Burda coated the interiors of extremely finely drawn-out glass micropipettes with lead selenide nanoparticles. Lead selenide is a semiconductor that is activated by IR light. As in solar cells, irradiation “catapults” firmly bound electrons out of the valence band and into the conduction band of the semiconductor, where they can move freely. This leads to charge separation and thus to an electrical potential. With a suitable laser, defined processes elicited by short light pulses set off corresponding electrical pulses in the micropipette. An electrical field is thus formed around the pipette, which can then be used by the researchers to stimulate neurons in rat brain samples with a high degree of time-resolution.

...By using these new photoelectrodes, the cooperation of nerve cells can be studied. However, therapeutic applications are also possible: the probes could be used to activate individual regions of the brain or damaged or cut nerves to restore function - without the need for disturbing wires. _Physorg
Fascinating! The laser pulses are transmitted down the glass electrode to the special implanted semiconductor material, where it is transduced to an electrical potential. This potential then triggers nerve impulses -- apparently on a very fine time resolution scale.

Think about it for a moment. A cyborg could wear a fiberoptic receiver "cap", which can be activated with finely aimed laser light from some distance away, to provide the desired brain stimulus. Would it be possible to control a human brain with any degree of multi-sensory "conscious" awareness using this technique? Eventually, perhaps.

Although lasers require line of sight control, which restricts their use vis a vis RF controllers, the lack of need for surface electronics and power supply would seem to be a significan advantage for many purposes.

Cyborgs and Grobycs appear to offer far more promise than pure robotics, at this point in time. One normally thinks of military or law enforcement applications when thinking of a "six million dollar man" with external neural triggers or shutoffs. But as more is learned about the effect of brain stimulation, we are more likely to discover ways of enhancing normal brain function. At that point, the range of applications will broaden, and the waiting line of humans desiring augmentation is apt to grow rather long.

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21 November 2008

"Lay-On" Electrode Sheets: Neural Prosthetics

Brain electrodes that penetrate cortical tissue can quickly lose function due to scar tissue and "glommed on" bio-debris that collects over time and disrupts the electro-neural connection. If a longer-lasting direct-to-brain connection can be made using electrode sheets that merely "lay on" the surface of the cortex, then the less invasive approach would probably be the way to go.
Schalk and his colleagues studied epilepsy patients undergoing a procedure known as electrocorticography (ECoG), in which a flat array of electrodes is laid over an exposed section of cortex to record electrical activity. Normally, surgeons use this information to pinpoint the source of seizures and to map the location of specific brain functions, which must be avoided during surgery. The technique generates a better spatial resolution than electroencephalography (EEG), a noninvasive approach that records activity through the scalp. ECoG is now being explored for use in brain-computer interfaces. "There's a growing interest in use of ECoG signals because nothing penetrates into the brain, and that appeals to people more than penetrating electrodes," says Marc Schieber, a physician and scientist at the University of Rochester Medical School, who was not involved in the research.

... It's not yet clear that ECoG, which records extracellular electrical activity and thus averages information coming from different cells, will be able to provide the same accuracy as implanted electrodes, which record activity from single cells. "As far as limb control, I think it will be somewhat basic," says Andrew Schwartz, a neuroscientist at the University of Pittsburgh.

However, ECoG possesses some significant advantages. With implanted electrodes, the quality of the recorded signals degrades over time, and the stiff electrodes can sometimes move within the squishy brain, thus requiring recalibration of the system. ECoG devices are less sensitive to movement. And because they lie on the surface of the brain, they may be less susceptible to the immune reaction thought to impair implanted electrodes. "Surface electrodes are more likely to be fit for long-term use," says Schalk.

Miniaturized ECoG devices now under development may make this technology even more appealing. With the current procedure, a surgeon must remove a large piece of skull to insert the electrode array. But Justin Williams, a biological engineer at the University of Wisconsin-Madison, is developing a miniature ECoG device that could be fed through a small hole in the skull and then unfurl to cover a larger area of the cortical surface. Made of platinum wires embedded in a flexible polymer called polyimide, which is frequently used in electronics, the electrode array is flexible and sticks to the wet brain. That means it moves as the brain moves, capturing a better signal. "It acts like Saran wrap on a Jell-O mold," says Williams. _TechnologyReview
The problem is one of signal to noise, and resolution of complex signals. Penetrating electrodes are better than "lay-on" cortical electrode sheets (ECoG), which in turn are better than scalp electrodes (EEG). The ECoG approach when combined with advanced computational filters and "translators" may be the best approach for short-term to mid-term neural prosthesis research--until better penetrating electrodes are devised.

My preference for penetrating electrodes is using the individual's own neural stem cells to grow connections from an interfacing device fixed to the skull--actually functioning as a replacement for a small area of skull--which contains both living neural tissue and the electro-neural interfacing technology. Such a unit could be easily detached from the skull and serviced without involving major surgery.

For more on this general topic, see Brain Stimulant blog

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