21 February 2008

miRNAs and Brain Neurodegenerative Disease

Parkinson's, Alzheimer's--neurodegenerative diseases that cause enormous disability and suffering. New findings in micro-RNA (miRNA) may provide researchers with more therapeutic targets, to combat the neurodegeneration caused by these and other brain diseases.
Micro-RNAs are a hot topic in almost every field of molecular biology right now; we’ve discussed them before here in the context of buffering age-related changes in gene expression. These novel regulatory molecules may also play a critical role in neurodegenerative disease, as described in this conference proceedings review by Pete Nelson and co-workers:

MicroRNAs (miRNAs) in Neurodegenerative Diseases

Aging-related neurodegenerative diseases (NDs) are the culmination of many different genetic and environmental influences. Prior studies have shown that RNAs are pathologically altered during the inexorable course of some NDs. Recent evidence suggests that microRNAs (miRNAs) may be a contributing factor in neurodegeneration. miRNAs are brain-enriched, small (22 nucleotides) non-coding RNAs that participate in mRNA translational regulation. Although discovered in the framework of worm development, miRNAs are now appreciated to play a dynamic role in many mammalian brain-related biochemical pathways, including neuroplasticity and stress responses. Research about miRNAs in the context of neurodegeneration is accumulating rapidly, and the goal of this review is to provide perspective for these new data that may be helpful to specialists in either field. An overview is provided about the normal functions for miRNAs, including some of the newer concepts related to the human brain. Recently published studies pertaining to the roles of miRNAs in NDs––including Alzheimer’s disease, Parkinson’s disease and triplet repeat disorders—are described.___Ouroborus
Noncoding RNAs perform many epigenetic and regulatory functions. This relatively new field within genetics is providing a lot of discoveries and new potential therapeutic options.

Update: This recent SEED article by Philip Ball reveals even more complexities in RNA's influence on heredity. Worth a look.

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