NEPPs, A Possible Palliative for Neurological Injury
The research team discovered that certain electrophilic compounds, NEPPs (NEurite outgrowth-Promoting Prostaglandins), induce nerves cells in the brain and the spine to release natural antioxidants that protect these cells from the free radical stress that results from excitotoxicity by activating the Keap1/Nrf2 pathway which regulates the production of these antioxidants.
“This is the first reported evidence that this protective response can be activated directly in nerve cells to release antioxidants and counter oxidative stress,” says Stuart Lipton, M.D., Ph.D., senior author of the study and director of the Del E. Webb Center for Neurosciences and Aging at the Burnham Institute.
This abstract discusses parallel research on NEPPS from Japan.
The molecular level of life is a complex balance of conflicting chemical and physical reactions. When the balance is disturbed, as in disease processes, a profound knowledge of this underlying balance is necessary in order to utilise the inbuilt protectors of vital cells.