Sex on the Brain: Apomorphine as Life Extension Aphrodisiac

Apomorphine is an old drug, dating at least back to the 1860s. It has found many uses, including as a treatment for Parkinson's Disease, and a treatment for Erectile Dysfunction. Apomorphine is also an efficient emetic at proper doses. In the context of life extension and longevity, apomorphine has proven to be a good trigger for HGH release. The drug may find uses in cases of stroke and myocardial infarction. Apomorphine is not an opiate analgesic like morphine, and is not addictive.

I suspect that apomorphine will find many more uses, given its multiple potencies. A good sex life is important for a satisfying life, whatever its length, and apomorphine not only induces penile erection, it also is a dopamine agonist, which suggests that the sex drive itself would be stimulated by apomorphine, and the sex act made more pleasurable.

Given the emetic properties of higher doses of apomorphine, it is not likely to become a drug of abuse. And given the several decades since its initial use in humans, the more lethal and disabling side effects of a drug would have been found. In other words, we have a drug, apomorphine, that likely has a positive effect on longevity via HGH release, and a positive effect on sexual desire, performance, and pleasure. Yet very few people have heard of apomorphine.

Here is some recent research on apomorphine from Shanghai:

Apomorphine (APO), a potent D1/D2 dopamine receptor agonist, is currently used as an antiparkinsonian drug. We have shown previously that APO stimulates synthesis and release of multiple trophic factors, such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF), in both mesencephalic and striatal neurons, thereby effectively preventing dopaminergic neuron loss in vitro. The present study was designed to investigate the effects of APO on fibroblast growth factor-2 (FGF-2) expression and regulation in astrocytes, and furthermore, to identify signaling mechanisms underlying these effects. Here, we show that FGF-2 expression is robustly induced in cultured astrocytes in response to APO. FGF-2 expression was proportional to APO concentration and time-dependent. More at source.

One more thing: apomorphine has been found to be protective of mitochondria in central nervous system neurons and heart muscle. Consider the implications of that when you are putting together your life extension kit.